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T1 is predominantly expressed in the brain and may act as a dominant negative inhibitor of BDNF signalling by forming heterodimers with full-length TrkB (31)

The authors concluded that the overall antioxidant defense system in DM2 is unable to counteract the increased production of ROS

NF-B is activated by three pathways: the canonical pathway (by TNF-, IL-1, or TLRs), the noncanonical pathway (by CD40L, BAFF, and RANKL), and the oxidative modification of DNA-binding residue-mediated activation by redox reactions [203])

Seufert J, Lanzinger S, Danne T et al (2022) Real-world data of 12-month adjunct sodium-glucose co-transporter-2 inhibitor treatment in type 1 diabetes from the German/Austrian DPV registry: improved HbA1c without diabetic ketoacidosis